Background

Endothelial dysfunction is associated with cardiovascular disease and cardiac events. Numerous studies demonstrate that a reduction in physical activity/exercise levels are associated with poor endothelial function. Yet, these studies use a plethora of models to mimic reduced activity levels which may have widely different results on endothelial function. It is pertinent to collectively review these articles to provide a comprehensive understanding of the impact of reduced activity on vascular health, as endothelial function is one of many factors that influences vascular tone.

Objective

The purpose of this systematic review is to examine and synthesize the current literature regarding the effects of acutely (≤ ~ 2 months) reducing physical activity on endothelial function.

Methods

This systematic review contains a search of two databases (PubMed, Web of Science) conducted by two reviewers. After screening and review, the search yielded 20 studies that were appraised and reviewed.

Results

Articles were separated into four categories based on the type of inactivity intervention: reduction in daily physical activity interventions, detraining (removal of exercise) interventions, bed rest interventions, and immobilization interventions. Acute physical inactivity interventions were largely shown to reduce upper and lower limb artery flow-mediated dilation and lower limb microvascular function.

Conclusion

The results indicate that those studies with increased time spent in inactivity, as well as increased severity of inactivity, were more likely to have negative endothelial function outcomes. Future research should examine differences in the severity of physical inactivity interventions regarding endothelial function.

中文翻译：

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身体不活动模型对内皮功能的影响：系统评价

  背景

内皮功能障碍与心血管疾病和心脏事件有关。大量研究表明，体力活动/运动水平的降低与内皮功能不佳有关。然而，这些研究使用了大量模型来模拟活动水平降低，这可能对内皮功能产生截然不同的结果。集体回顾这些文章以提供对活动减少对血管健康影响的全面理解是相关的，因为内皮功能是影响血管张力的众多因素之一。

  目的

本系统综述的目的是检查和综合当前关于急性 （≤ ~ 2 个月） 减少体力活动对内皮功能影响的文献。

  方法

本系统综述包含由两位评价员对两个数据库（PubMed、Web of Science）进行的检索。经过筛选和评价，检索产生了 20 项研究，这些研究进行了评价和评价。

  结果

根据不活动干预的类型，将文章分为四类：减少日常身体活动干预、减少训练（取消运动）干预、卧床休息干预和制动干预。急性身体活动不足干预在很大程度上显示可以减少上肢和下肢动脉血流介导的扩张和下肢微血管功能。

  结论

结果表明，那些不活动时间增加以及不活动严重程度增加的研究更有可能产生负面的内皮功能结局。未来的研究应检查身体不活动干预对内皮功能严重程度的差异。