Chlordecone (CLD) is an organochlorine pesticide with various toxicities, widely used from 1972 to 1993 in the French West Indies lands (FWI, Guadeloupe and Martinique). It can remain in environment leading to indoor contamination by pollutants coming from outside. Therefore, investigating indoor pollutants is necessary due to the potential indoor dust ingestion though hand-to-mouth contact, in particular for children. No chemical analytical methods measure CLD in indoor dust and we propose to investigate its presence in this specific compartment, in Martinique. CLD was analyzed from dust samples taken from homes and schools (n=47). We extracted CLD from dust with pressure liquid extraction (PLE) using a suitable mixture solvent of hexane and ethyl acetate (85:15). This was followed with gas chromatography coupled to tandem spectrometry (GC/MS/MS) analysis. A sampled mass of 25 mg optimal for analysis. Concentrations of CLD in indoor dust varied from < 16 to 247 ng/g. Exposure to CLD through indoor dust ingestion was also assessed and does not exceed 1.5% and 0.1%, of the acceptable daily intake, in childrens and adults, respectively. However, this exploratory study was conducted on a very limited number of dust samples limits the generalizationto the whloe French West Indies population.

中文翻译：

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法属西印度群岛 GC/MS/MS 测定室内粉尘中十氯酮的含量以及相关的人体暴露量

十氯酮 （CLD） 是一种具有多种毒性的有机氯杀虫剂，1972 年至 1993 年在法属西印度群岛地区（FWI、瓜德罗普岛和马提尼克岛）广泛使用。它可以留在环境中，导致室内受到来自外部的污染物的污染。因此，调查室内污染物是必要的，因为手口接触可能会摄入室内灰尘，尤其是对于儿童。没有化学分析方法可以测量室内灰尘中的 CLD，我们建议在马提尼克岛的这个特定隔间中调查其的存在。从家庭和学校采集的灰尘样本中分析 CLD （n=47）。我们使用合适的己烷和乙酸乙酯混合溶剂 （85：15） 通过加压液体萃取 （PLE） 从粉尘中提取 CLD。然后进行气相色谱-串联光谱 （GC/MS/MS） 分析。采样质量为 25 mg，最适合分析。室内灰尘中 CLD 的浓度从 < 16 到 247 ng/g 不等。还评估了通过室内灰尘摄入暴露于 CLD 的情况，儿童和成人分别不超过可接受每日摄入量的 1.5% 和 0.1%。然而，这项探索性研究是在非常有限数量的尘埃样本上进行的，限制了对法属西印度群岛种群的推广。